Alexander Romanovich Luria: A Scientific Biography (Plenum by Evgenia D. Homskaya, David E. Tupper

By Evgenia D. Homskaya, David E. Tupper

Alexander Romanovitch Luria is widely known as one in all the main well-liked neuropsychologists of the 20th century. This ebook - written by means of his long-standing colleague and released in Russian by means of Moscow college Press in 1992, fifteen years after his loss of life - is the 1st critical quantity from outdoor the Luria kin dedicated to his existence and paintings and comprises the main accomplished bibliography to be had wherever of Luria's writings.

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The cell proliferation phase of this reparative process in mammals has been subjected to intensive kinetic and regulatory analyses ([87] and references therein). After tissue loss, residual hepatocytes are activated to proliferate within a few hours; hepatocyte proliferation begins at the portal ends of plates [83], and successive waves of hepatocyte proliferation ultimately involve virtually all residual hepatocytes [83, 90]. Hepatocyte replacement is followed sequentially by proliferation of sinusoidal endothelial cells and macrophages [83, 84], and the other cells of the parenchymal matrix.

Large afferent and efferent vessels hemodynamically divide the parenchyma into at least eight macrovascular segments, which enable the surgical resection of large portions (segments) of the blood-filled, sponge-like liver through hemodynamic fissures between afferent and efferent blood flows (see below). PHYLOGENESIS AND EVOLUTION OF THE LIVER The multiple functions of the mammalian liver are carried out by a combination of exocrine, endocrine, and paracrine/juxtacrine mechanisms involving the several types of cell listed above, as well as stromal cells (fibroblasts), and cells forming nerves and large blood vessels.

The pressure of portal venous blood is reduced as the major afferent vessels dichotomize through the parenchyma, from about 130 mm of water in the extrahepatic portal vein to about 60 mm of water in the preterminal portal veins of the exteriorized liver of the anesthetized rat, amounting to about 60% of the total transhepatic pressure gradient [44]. A similar portal pressure gradient has been found in humans [43]. Blood flow through the liver amounts to about 1500–2000 ml minute−1 in adult humans, about 25% of the resting cardiac output [43].

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